The chemical inhibition of the repair of single-strand breaks in DNA: post-irradiation sensitization to x-rays.
نویسندگان
چکیده
A class of radiosensitizers is discussed which irreversibly inhibits the repair of x-ray-induced single-strand breaks in DNA. Such agents are active when added after irradiation and potentiate x-ray-induced killing in rec + strains of E. coli K-12, but have little effect on the viability of x-irradiated recA strains which are deficient in their ability to repair x-ray-induced single-strand breaks. Chromatographically-impure samples of hydroxyurea (but not pure samples) have the properties associated with this class of post-irradiation sensitizers.
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ورودعنوان ژورنال:
- International journal of radiation biology and related studies in physics, chemistry, and medicine
دوره 19 3 شماره
صفحات -
تاریخ انتشار 1971